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Epigenetic alterations Cancer initiation and progression are caused not solely by UV-induced mutations in significant genes but also by the subsequent alterations in epigenetics, which result in their abnormal expression patterns conducive to cancer development and aggressive behavior

Numerous studies revealed that cancer is the results of oxidative DNA damage by ROS, in which hydroxylation of bases of DNA molecule take place followed by change in DNA structure

These beneficial effects were abolished when inhibition was performed by using Nrf2-siRNA

K.ChangA.SloanE

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